Comparison of cardiac function and structure after left atrial appendage occlusion without versus with ablation in patients with non-valvular atrial fibrillation: a retrospective study

Author:

Ruan Zhong-bao1,Wang Fei1,Chen Ge-cai1,Zhu Jun-guo1,Ren Yin1,Zhu Li1

Affiliation:

1. the affiliated Taizhou People's Hospital of Nanjing Medical University, Nanjing Medical University

Abstract

Abstract Background Regarding the physiology role of left atrial appendage (LAA), whether occlusion of LAA or combined with ablation has any influence on cardiac function and structure in patients with non-valvular atrial fibrillation (NVAF) is still unclear. Aims To compare the influence on cardiac function and structure after left atrial appendage occlusion (LAAO) without versus with ablation in patients with NVAF. Methods 157 patients with NVAF who underwent LAAO or combined with ablation were included and divided into Simple LAAO group or Combined group. Long term impact on cardiac function and structure between the two groups were compared. Results There was a significant decrease of left atrial anteroposterior diameter (LAAD) at 6 months and a significant increase of left ventricular end-diastolic dimension (LVEDD) at 12 months after LAAO. A significant decrease in plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) was noted at 3 months, 6 months and 12 months after LAAO. Subgroup analysis indicated that there was a significant decrease of LAAD, LVEDD, LVESD and NT-proBNP levels in Combined group at 3 months, 6 months and 12 months post-procedure, while an increase of LVEF. However, no significant change of LAAD, LVEDD, LVESD, NT-proBNP and LVEF was seen in Simple LAAO group at 3 months follow-up, but a decrease of NT-proBNP during 6 months and 12 months follow-up. Compared with Simple LAAO group, Combined group was associated with a significant increase of residual flow. Conclusions LAAO has no significant effect on cardiac structure and function but can significantly reduce NT-proBNP. The improvement of cardiac structure and function in combined therapy comes from the influence of ablation, not LAAO.

Publisher

Research Square Platform LLC

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3