IAMPDB: A Knowledgebase of Manually Curated Insects-Derived Anti-Microbial Peptides

Author:

Samanta Sintu Kumar1,Mondal Rajat Kumar1,Tripathi Prabhat1,Mondal Rudra Prasad,Sen Debarup2,Arya Ankish1,Karmakar Debayan1,Pal Oshin1,Dey Avijit3

Affiliation:

1. Indian Institute of Information Technology, Allahabad

2. Persistent Systems Ltd

3. Ramakrishna Mission Vidyamandira

Abstract

Abstract

Insects, a majority of animal species, rely on innate immunity and Anti-Microbial Peptides (AMPs), are a part of their innate immunity, to combat diverse parasites and pathogens. These peptides have applications ranging from agriculture to anti-microbial resistance. However, there's a lack of a specialized database, prompting the development of the Insect Anti-Microbial Peptide Database (IAMPDB) as a pioneering comprehensive Knowledgebase dedicated to Insect-derived Anti-Microbial Peptides (IAMPs), serving as a resource for researchers and industry professionals. Curated from UniProt and associated literature(s), IAMPDB currently houses 438 curated entries of IAMPs from various insect species, spanning 10 taxonomical orders of insects. Each entry is meticulously annotated with details on peptide sequences, source organisms, activities, physicochemical properties, and more. IAMPDB offers a user-friendly interface with diverse search options, interactive visualizations, and links to external databases; advanced tools, including a Peptide Sequence Alignment Toolbox and a Peptide Feature Calculation Toolbox, facilitating sequence alignment, physicochemical property calculation, and in-depth analysis. The knowledgebase is accessible at URL: https://bblserver.org.in/iampdb/.

Publisher

Springer Science and Business Media LLC

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