Abstract
Insects, a majority of animal species, rely on innate immunity and Anti-Microbial Peptides (AMPs), are a part of their innate immunity, to combat diverse parasites and pathogens. These peptides have applications ranging from agriculture to anti-microbial resistance. However, there's a lack of a specialized database, prompting the development of the Insect Anti-Microbial Peptide Database (IAMPDB) as a pioneering comprehensive Knowledgebase dedicated to Insect-derived Anti-Microbial Peptides (IAMPs), serving as a resource for researchers and industry professionals. Curated from UniProt and associated literature(s), IAMPDB currently houses 438 curated entries of IAMPs from various insect species, spanning 10 taxonomical orders of insects. Each entry is meticulously annotated with details on peptide sequences, source organisms, activities, physicochemical properties, and more. IAMPDB offers a user-friendly interface with diverse search options, interactive visualizations, and links to external databases; advanced tools, including a Peptide Sequence Alignment Toolbox and a Peptide Feature Calculation Toolbox, facilitating sequence alignment, physicochemical property calculation, and in-depth analysis. The knowledgebase is accessible at URL: https://bblserver.org.in/iampdb/.