Abstract
Abstract
Background: Stearoyl-CoA desaturase 1 (SCD1) activity, a key lipid metabolism regulator, may impact type 2 diabetes (T2D). Previously, we reported a significant functional interaction between SCD1 and T2D in the Bangladeshi population. In the present study, we investigated the relationship between the SCD1 rs7849 polymorphism and T2D risk variables (n = 90; mean age, 45 y; range, 30–70 y).
Methods: 45 T2D patients and 45 healthy controls were recruited. Demographic and anthropometric data of the subjects were recorded and biochemical parameters were measured following standard protocols. Genomic blood DNA was extracted by PCR-RFLP method to identify the SCD1 gene rs7849 polymorphic variant and Hardy-Weinberg Equilibrium for SCD1 gene variants was tested.
Results: The results showed that the heterozygous allele (TC) for SCD1 at position 7849 has been associated with higher postprandial blood glucose levels (p-value < 0.05). Healthy non-diabetic individuals with the SCD1 rs7849 variant had higher BMIs than their diabetic counterparts (p-value < 0.05). Females with rs7849 heterozygous variants had significantly higher body composition and body fat distribution when compared between the genders (p-value < 0.05).
Conclusions: This preliminary research from Bangladesh raises the possibility that genetic variations in the SCD1 gene may affect the propensity to type 2 diabetes.
Publisher
Research Square Platform LLC
Reference48 articles.
1. Shafrir E, Raz I. Diabetes: Mellitus or lipidus? Diabetologia. 2003;46(3):433–40.
2. Oxidative capacity, lipotoxicity, and mitochondrial damage in type 2 diabetes;Schrauwen P;Diabetes,2004
3. Ectopic fat accumulation: An important cause of insulin resistance in humans;Yki-Järvinen H;J R Soc Med Suppl,2002
4. Pancreatic β-cell lipotoxicity induced by overexpression of hormone-sensitive lipase;Winzell MS;Diabetes,2003
5. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity;Yamauchi T;Nat Med,2001