A meta-analysis on genetic susceptibility to chronic otitis media

Abstract

Abstract Chronic otitis media (COM) is known for its high prevalence (approximately 80% in children) and is thought to share common genetic risk factors, which means that there is a need to systematically study susceptibility genes associated with COM. We screened studies associated with COM genes between January 2019 and February 2023. Ten papers with 932 patients meeting the criteria were finally included, and a case-control analysis of the relationship between gene polymorphisms and COM susceptibility was performed using RevMan 5.3 software. The literature on the relationship between polymorphisms in genes related to susceptibility to chronic otitis media and chronic otitis media was tested for consistency and data merged according to different genes, and some genes were found to be polymorphic. Attitude, VEGF and Nrf2 were correlated with chronic otitis media (P < 0.05). Gene polymorphism and chronic otitis media may be related to the nationality of patients; TNF- α, IL-10, VEGF and Nrf2 may promote the formation of granulation tissue during the inflammatory phase and participate in the repair process of chronic inflammation; high expression of Nrf2 in the middle ear tissue of chronic otitis media is related to the pathogenesis of chronic otitis media.