Association between CD103 and E-cadherin Immunoexpression with Pelvic Lymph Node Metastasis in Cervical Squamous Cell Carcinoma-Reference-Cited by-同舟云学术

Association between CD103 and E-cadherin Immunoexpression with Pelvic Lymph Node Metastasis in Cervical Squamous Cell Carcinoma

Published:2024-07-02 Issue: Volume: Page:
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Author:

Yantisetiasti Anglita¹,Rej Henny Sri¹,Suryanti Sri¹,Dewayani Birgitta Maria¹,Winarno Gatot Nyarumenteng Adhipurnawan¹,Kireina Jessica¹,Chandra Anita Riau¹,Mantilidewi Kemala Isnainiasih¹,Hernowo Bethy Suryawathy¹,Susiarno Hadi¹

Affiliation:

1. Padjadjaran University

Abstract

Background Lymph node (LN) metastasis is a poor prognostic factor for cervical squamous cell carcinoma (SCC). One important predictor of LN metastasis is lymphocytic inflammatory reaction, which may be indicated by infiltration of CD103 + CD8 + T cells. CD103 will bind to its ligand, E-cadherin which causes enhancement of CD8 + T cells cytotoxic function against tumor cells. This study aims to examine the relationship between CD103 and E-cadherin immunoexpression with pelvic LN metastases in cervical SCC. Methods A formalin-fixed paraffin-embedded (FFPE) cervical SCC of the patients who underwent hysterectomy and lymphadenectomy between 2013 and 2018 at Dr. Hasan Sadikin General Hospital, Bandung were analyzed. Twenty FFPE with LN metastasis were analyzed and equal number of control were compared. All samples were immunostained with CD103 and E-cadherin and immunoexpression was analyzed by Kolmogorov Smirnov and Chi-square. The p-value of 0.05 was considered significant. Results This study showed a significant association between CD103 immunoexpression and pelvic LN metastases (p < 0.01). There was no significant relationship between E-cadherin immunoexpression and pelvic LN metastases (p > 0.05). Conclusion Our study revealed that CD103 immunoexpression in cervical SCC is associated with pelvic LN metastases in cervical SCC by a mechanism that may not require E-cadherin expression.

Publisher

Research Square Platform LLC

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