Abstract
Toxoplasmosis is a rare parasitic disease that can cause fatal multi-organ failure in immunocompromised patients. Non-specificity of the symptoms and confirm diagnosis of tachyzoites in fluids or tissues by microscopic examination resulting in a delay before diagnosis.
A 28-year-old woman with severe aplastic anemia received stem cell transplantation seven months ago, presented with fever.Computed Tomography scan and ultrasonography showed moderate pleural, pericardial, peritoneal, and pelvic effusions. Metagenomic next generation sequencing of blood and alveolar lavage fluid were done, 11082 and 17154 sequence readings of toxoplasma gondii were detected and accounting for 1.34% and 17.09% of genome coverage respectively. Then, Marrow aspirate smears showed toxoplasma gondii tachyzoites and pseudocyst.
These data confirm that highlights the need for enhance vigilance against toxoplasma gondii infection in stem cell transplantation patients with multiple serous effusions and fever.