Association between percent body fat and the risk of prediabetes among Chinese adults: a 5-years longitudinal cohort study

Author:

Li Xin1,Yu Haomiao1,Yu Ke1,Huang Zhenhua1,Deng Zhe1

Affiliation:

1. Shenzhen Second People’s Hospital & The First Affiliated Hospital of Shenzhen University

Abstract

Abstract

Background Our study aimed to explore the potential influence of percent body fat (PBF) on the risk of developing prediabetes in Chinese individuals, considering the scarce evidence available on this relationship. Methods This study included 184,268 Chinese adults in a retrospective cohort design. We used Cox proportional hazards regression models along with cubic spline functions and smooth curve fitting to examine the correlation between initial PBF and the likelihood of prediabetes, investigating its nonlinear connection. We performed a variety of sensitivity and subgroup analyses to confirm the strength of our results. Results After adjusting for covariates, the study found a positive correlation between the PBF and the risk of prediabetes (HR = 1.29, 95%CI: 1.25–1.32, p < 0.0001).The risk of prediabetes increased progressively across quartiles of the PBF (Q1 to Q4), with Q4 showing a significantly higher risk compared to Q1.Additionally, there was a nonlinear correlation found between PBF and the likelihood of prediabetes, showing a turning point at 29.5.On the left side of the turning point, the hazard ratio was 1.13 with a 95% confidence interval from 1.08 to 1.19, whereas on the right side, the hazard ratio was 1.49 with a 95% confidence interval from 1.41 to 1.57.Interaction analysis showed that gender interacted with PBF. Conclusion In our research, we discovered a curved connection between PBF and the emergence of prediabetes in Chinese people, with a turning point at 29.5. Reducing PBF to below 29.5 may help maintain a lower risk of developing prediabetes.

Publisher

Springer Science and Business Media LLC

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