Abstract
Objectives To research the pathogen distribution and Mycoplasma resistance of reproductive tract infection in infertile women in Wenzhou in recent years, and to provide experimental basis for clinical medication.
Methods Infertility patients diagnosed in the Second Affiliated Hospital of Wenzhou Medical University from January 2020 to December 2021 were selected. Cervical secretions were collected for pathogen detection and mycoplasma drug sensitivity test.
Results 4154 cases of reproductive tract infection were detected in 7073patients, with an infection rate of 58.73%. Mycoplasma infection(49.88%) was the most common, the main mode of CT infection was CT+UU with a positive rate of 1.40%. 595 cases were infected with two or more pathogens, and the mixed infection rate was 8.41%.The infection rates of UU, CT, UU+MH, UU+CT, UU+MH+CT (67.21%, 0.59%, 7.83%, 2.26%, 0.95%) in women with tubal infertility were higher than those in women with non-tubal infertility (P<0.05). There was no difference in the incidence of MH and NG between the two groups (P>0.05). The drug sensitivity test showed that there were many sensitive drugs to UU, including minocycline (98.57%), doxycycline (98.50%), josamycin (94.51%), azithromycin (78.82%) and erythromycin (70.69%). However, UU+MH mixed infection was severely resistant sensitive to azithromycin, erythromycin, clarithromycin and rohong, only sensitive to minocycline (98.05%), doxycycline (98.70%) and josamycin (88.50%).
Conclusion Common venereal pathogens genital tract infection is closely related to infertility, UU infection is the most common, multiple pathogens mixed infection is very common and serious drug resistant. It is suggested to select sensitive antibiotics to reduce the generation of drug-resistance strains according to the results of drug sensitivity test.