Utility of a rapid assay for Prostaglandin E-major urinary metabolite as a biomarker in pediatric ulcerative colitis-Reference-Cited by-同舟云学术

Utility of a rapid assay for Prostaglandin E-major urinary metabolite as a biomarker in pediatric ulcerative colitis

Published:2023-02-13 Issue: Volume: Page:
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Author:

Hagiwara Shin-ichiro¹,Abe Naoki²,Hosoi Kenji³,Hara Tomoko⁴,Ishige Takashi⁵,Shimizu Hirotaka⁶,Mizuochi Tatsuki⁷,Kakiuchi Toshihiko⁸,Kunisaki Reiko⁹,Matsuoka Ryo¹⁰,Kondou Hiroki¹¹,Kakuta Fumihiko¹²,Nakayama Yoshiko¹³,Kimura Takeshi¹⁴,Honma Hitoshi¹⁵,Hirano Daishi¹⁶,Saruta Masayuki¹⁷,Yoshida Tsutomu¹⁸,Okayasu Isao¹⁹,Etani Yuri¹⁵,Maeyama Takatoshi¹

Affiliation:

1. Osaka Women’s and Children’s Hospital

2. Aichi Children’s Health and Medical Center

3. Tokyo Metropolitan Children's Medical Center

4. Saitama Children's Medical Center

5. Gunma University Graduate School of Medicine

6. National Center for Child Health and Development

7. Kurume University School of Medicine

8. Saga University

9. Yokohama City University Medical Center

10. Fuji City Central Hospital

11. Kindai University Nara Hospital

12. Miyagi Children's Hospital

13. Shinshu University School of Medicine

14. Osaka University Graduate School of Medicine

15. Osaka Women's and Children's Hospital

16. Jikei University School of Medicine

17. The Jikei University School of Medicine

18. Research and Development Center for New Medical Frontiers, Kitasato University School of Medicine

19. Kitasato University School of Medicine

Abstract

Abstract Prostaglandin E-major urinary metabolite (PGE-MUM) is a urinary biomarker reflecting ulcerative colitis (UC) activity. This prospective observational study aimed to evaluate the usefulness of PGE-MUM via rapid chemiluminescent enzyme immunoassay in detecting endoscopic remission (ER) and histologic remission (HR) in pediatric UC (6–16 years) in comparison with fecal calprotectin (FCP). ER and HR were defined as Mayo endoscopic score (MES) of 0 and Matts’ histological grades (Matts) of 1 or 2, respectively. A total of 104 UC and 39 functional gastrointestinal disorder (FGID) were analyzed. PGE-MUM levels were significantly higher in the UC group than in the FGID group (P < 0.001). FCP levels were significantly elevated in the group without ER and HR than in the group with ER and HR (P < 0.001 and P = 0.001), whereas PGE-MUM levels were significantly higher in the group without ER compared to the group with ER (P < 0.001). No significant differences were noted in the AUCs for PGE-MUM and FCP in detecting ER and HR. Although PGE-MUM was inferior to FCP for the detection of HR, it might have the potential for application as a biomarker of endoscopic activity in pediatric UC owing to its noninvasive and rapid method.

Publisher

Research Square Platform LLC

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