Affiliation:
1. Harbin Medical University
Abstract
Abstract
The neurovascular unit (NVU) is involved in the pathological changes in Alzheimer’s disease (AD). The NVU is a structural and functional complex that maintains microenvironmental homeostasis and metabolic balance in the central nervous system (CNS). As one of the most important components of the NVU, microglia not only induce BBB breakdown by neuroinflammation, the infiltration of peripheral WBCs and oxidative stress but also mediate neurovascular uncoupling by damage neurons, abnormal contraction of cerebral vessels and pericyte loss in AD. In addition, microglia-mediated dysfunction of cellular components in the NVU, such as astrocytes and pericytes, can destroy the integrity of the NVU and lead to NVU dysfunction. Therefore, we examined microglia to clarify the mechanism of NVU dysfunction in AD. Furthermore, existing medication advancements aimed at restoring the function of microglia and the NVU in AD are discussed.
Publisher
Research Square Platform LLC
Reference143 articles.
1. Uber eine eigenartige Erkrankung der Hirnrinde;Alzheimer A;Allgemeine Zeitschrife Psychiatrie,1907
2. Alzheimer's disease;Hodson R;Nature,2018
3. 2020 Alzheimer's disease facts and figures;Alzheimers Dement. doi,2020
4. Soto-Rojas LO, Pacheco-Herrero M, Martínez-Gómez PA, Campa-Córdoba BB, Apátiga-Pérez R, Villegas-Rojas MM, Harrington CR, de la Cruz F, Garcés-Ramírez L and Luna-Muñoz J (2021) The Neurovascular Unit Dysfunction in Alzheimer's Disease. Int J Mol Sci 22. doi: 10.3390/ijms22042022.
5. Neurovascular dysfunction and neurodegeneration in dementia and Alzheimer's disease;Nelson AR;Biochim Biophys Acta,2016
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