NELL-1 Associated Membranous Nephropathy: A case report of Lipoic Acid-Induced Nephrotic Syndrome

Abstract

Membranous nephropathy (MN) often arises from secondary causes such as hepatitis, HIV or heavy metal poisoning, but occasionally occurs without any identifiable underlying cause. Typically, more than 70% of cases are positive for phospholipaseA2 receptor 1(PLA2R1) and thromboplastin type 1 domain-containing protein 7 A (THSD7A). However, emerging evidence suggests associations with novel biomarkers. We present a case in which MN was associated with NELL-1 expression due to lipoic acid use (LA), highlighting the importance of identifying emerging biomarkers for MN diagnosis and timely initiation of appropriate treatment. Clinical Trial Number: Not applicabale