Neuroprotective Effects of Sinapic acid and Ursolic acid in Vanadium-Induced Neurotoxic effect in Rat.

Abstract

Abstract The antioxidant and anti-inflammatory agent may be an effective combination against neuroinflammation and oxidative stress in neurotoxicity. Sinapic acid acts as a potential antioxidant and ursolic acid acts as an anti-inflammatory agent. In this study, we investigate the neuroprotective effect of SA and UA against vanadium-induced neurotoxicity. 56 male Wistar rats were equally divided into eight groups and received Sodium metavanadate along with Sinapic Acid and Ursolic Acid. Various behavioural and biochemical parameters were evaluated and histology for the same was performed. Administration of SMV led to a decline in behavioural patterns and resulted in impaired memory assessed by the behavioural study. Treatment with SA and UA as monotherapy and combination dose, increased activity of antioxidant enzymes and anti-inflammatory activity was observed with decreased expression of TNF-α and IL-1β.The current study indicates a possible additive effect of Sinapic Acid + Ursolic Acid in combination dose, exerting a protective effect by improving cognitive decline, locomotor activity, and improving oxidative stress in vanadium-induced neurotoxicity.