Biomechanical evaluation of the effect of a stem cell enhancer on bone implant connection of titanium implants

Abstract

Abstract Background This study aimed to conduct a biomechanical investigation of the effects of stem cell enhancer (SCE) application on osseointegration of titanium implants in rat tibias. Methods After surgical implantation of titanium implants in the metaphyseal part of the tibiae of rats, the rats were randomly divided into three equal groups (n = 10): control group, SCE Dosage group 1 (SCE1), and SCE Dosage group 2 (SCE2). Each group consisted of 10 rats. The rats in the SCE1 and SCE2 groups were administered 6 mg and 12 mg SCE (Stemregen®), respectively, every day during the four-week of experimental period after surgery. Implants and surrounding bone tissues were collected for biomechanical bone-implant connection analysis at the end of the experimental procedures. One-way ANOVA was used for statistical analysis. Results There was no significant difference in the biomechanical osseointegration values of the groups; however, the osseointegration of the SCE group was better than that of the control group. Conclusions Stem cell enhancers have the potential to improve the biomechanical bone-implant interface.