Synthesis, characterization and biological activities of novel mononuclear nickel(II), copper(II) and chromium(III) complexes with N,N-dilaurylsubstituted thiazolidine-4-one-5-acetic acid ligand

Abstract

For the first time, a thiazolidine-4-one-5-acetic acid with two long hydrocarbon chains was chosen as ligand and the corresponding metal complexes with Cr(III), Ni(II) and Cu(II) salts were prepared. Analytical and spectroscopic studies have shown that the metal complexes are most likely to have a distorted octahedral geometry comprised of carboxylate and amide carbonyl O atoms and four isopropyl alcohol ligands inside the coordination sphere. According to molar conductivity measurements, all three complexes are not electrolyte in nature. The newly prepared complexes have been tested for their antifungal and antibacterial activity against C. albicans and S. aureus respectively. The Ni(II) complex exhibited good antifungal activity against C. albicans, while the Cu(II) complex showed better antibacterial activity against S. aureus than the other complexes.