Association of Maternal Pre-Pregnancy or First Trimester Body Mass Index with Neurodevelopmental Outcome in Extremely Low Gestational Age Neonates-Reference-Cited by-同舟云学术

Association of Maternal Pre-Pregnancy or First Trimester Body Mass Index with Neurodevelopmental Outcome in Extremely Low Gestational Age Neonates

Published:2023-08-07 Issue: Volume: Page:
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Author:

Chawla Sanjay¹,Laptook Abbot²^ORCID,Smith Emily,Tan Sylvia,Natarajan Girija³^ORCID,Wyckoff Myra⁴,Greenberg Rachel⁵^ORCID,Ambalavanan Namasivayam,Bell Edward⁶^ORCID,Meurs Krisa Van⁷^ORCID,Hintz Susan⁸^ORCID,Vohr Betty⁹^ORCID

Affiliation:

1. American Academy of Pediatrics

2. Women and Infants Hospital of RI

3. Central Michigan University

4. University of Texas Southwestern Medical Center

5. Duke University

6. University of Iowa

7. Stanford University School of Medicine and Lucile Packard Children'

8. Stanford University

9. Alpert Medical School of Brown University, Women and Infants Hospital

Abstract

Abstract Objective: To compare the rates of death or survival with severe neurodevelopmental impairment (sNDI) at 2 years among extremely preterm infants in relation to pre-pregnancy or first trimester maternal body mass index (BMI). Methods: This retrospective cohort study included extremely preterm infants (gestational age 220/7-266/7 weeks). The study was conducted at National Institute of Child Health and Human Development Neonatal Research Network sites. The primary outcome was death or sNDI at 2 years. Results: Data on the primary outcome were available for 1,208 children. Death or sNDI was not different among the three groups: 54.9% in normal, 56.1% in overweight, and 53.4% in obese group (p=0.39). There was no significant difference in mortality, sNDI, moderate/severe cerebral palsy, Bayley Scales of Infant Development (BSID)-III cognitive composite score <70, BSID-III language composite score <70 in adjusted models. Conclusion: Neurodevelopmental outcome was not significantly associated with maternal pre-pregnancy BMI among extreme preterm infants.

Publisher

Research Square Platform LLC

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