Association of the Respiratory Severity Score with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension in Infants Born Extremely Preterm-Reference-Cited by-同舟云学术

Association of the Respiratory Severity Score with Bronchopulmonary Dysplasia-Associated Pulmonary Hypertension in Infants Born Extremely Preterm

Published:2023-04-27 Issue: Volume: Page:
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Author:

Kielt Matthew¹^ORCID,Beer Lindsey,Rivera Brian²,Jama Waceys³,Slaughter Jonathan⁴^ORCID,Backes Carl²,Conroy Sara⁴

Affiliation:

1. Nationwide Children's Hospital, The Ohio State University College of Medicine

2. Nationwide Children's Hospital

3. Abigail Wexner Research Institute at Nationwide Children's Hospital

4. The Ohio State University

Abstract

Abstract Objective: To test the hypothesis that elevations in the respiratory severity score (RSS) are associated with increased risk of bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH). Study Design: Retrospective cohort study of infants born extremely preterm admitted to a BPD center between 2010-2018. Echocardiograms obtained ≥36 weeks’ post-menstrual age (PMA) were independently adjudicated by two blinded cardiologists to determine the presence/absence of BPD-PH. Multivariable logistic regression estimated the association between RSS with BPD-PH. Result: BPD-PH was observed in 68/223 (36%) of subjects. The median RSS at time of echocardiography was 3.04 (Range 0-18.3). A one-point increase in RSS was associated with BPD-PH, aOR 1.3 (95% CI 1.2-1.4), after adjustment for gestational age and PMA at time of echocardiography. Conclusion: Elevations in the RSS were associated with a greater risk of BPD-PH. Prospective studies are needed to determine the validity and performance of RSS as a clinical susceptibility/risk biomarker for BPD-PH.

Publisher

Research Square Platform LLC

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