Affiliation:
1. Southwest Medical University
2. Chiang Mai University
3. Chengdu Medical College
Abstract
Abstract
SiJunZiTang (SJZT), a classic Chinese medicine formula widely used in clinic, has been proven to have therapeutic effects on HCC. However, the underlying mechanisms and molecular targets for therapy are still poorly understood. In this study, we used the strategy of integrated pharmacology to combine network pharmacology, molecular docking, machine learning and bioinformatics to reveal the immune mechanism of action of SJZT in the treatment of HCC and overcome the problem of the insufficient combination of network pharmacology and clinical information. We systematically studied the active components, potential targets and pathways of SJZT in the treatment of HCC. At same time, we found that SPP1, the hub target of SJZT in HCC treatment, was positively correlated with poor prognosis and could be an independent prognostic factor for HCC. SJZT therapies could synergistically halt HCC progression by simultaneously combating M2 macrophage infiltration and immune suppression in the HCC microenvironment. Our study provides a novel strategy for understanding the pharmacological properties of TCM and exploring effective treatment options for HCC.
Publisher
Research Square Platform LLC