An investigation of oxidative stress parameters and histopathological changes due to simultaneous exposure to toluene and loud noise in brain tissue of adult male rats

Abstract

AbstractBackground:Occupational and environmental exposures to organic solvents and noises in the workplace are major health issues. One of these solvents is toluene, and on top of that noise is an impartible part of any industry. the present study aims to determine the alteration of oxidative stress parameters and the histopathological changes caused by simultaneous exposure to toluene and noise in the brain tissue.Methods:For this purpose, 32 male Wistar rats were divided into four experimental groups and then were exposed to varying factors for 8 hours a day (8 h/day) for 28 days. These four groups were: 1) The control group, 2) The group exposed to noise (100dB), 3) The group exposed to toluene by inhalation (500 ppm), and 4) The group simultaneously exposed to both of them. In this study, the levels of lipid peroxidation (MDA) and glutathione (GSH) and the histopathological changes of the brain tissue were determined.Results:The findings suggest that, in the various parts of the temporal brain tissue simultaneously exposed to toluene and noise, the cohesion was more decreased compared to the tissues in other groups. Furthermore, in the group simultaneously exposed to both factors the MDA level increased and the GSH level decreased significantly.Conclusions:The results indicated the impact of synergistic interaction between noise and toluene on the accumulation of oxidation products, the progressive morphological damages as well as the weakening of the antioxidant defense system in brain tissues of rats and being simultaneously exposed to both factors has a cumulative effect