The Prevalence of Anti-Phospholipid Antibodies and Effects on the Outcomes of in Vitro Fertilization

Abstract

Abstract Background The problem of infertility is common worldwide. In vitro fertilization remains the most widely used technique of assisted reproductive technology. Embryo implantation failure is a common cause of unexplained infertility and recurrent miscarriages, thus the relationship between antiphospholipid antibodies and embryo implantation failure after in vitro fertilization and embryo transfer is an important problem in fertility medicine that must be studied. Patients and Methods The study included 1000 cases, of women that underwent IVF between 2017–2021, through a Cohort study. Results The average age of the women was 31.91, the success rate of assisted fertilization in inducing pregnancy in the last trial was 52.8%, the prevalence was 4.4% of anticardiolipin IgG, 2.6% of anticardiolipin IgM, and 4% of Lupus anticoagulant. No relation was found between the antiphospholipid value and the age of the women, the number of times the experiment was conducted, the rate of success and failure, the type of infertility, and the number of oocytes induction, while the duration of sterility was affected by positive values of IgG and lupus coagulant antibodies. Conclusion There is no need for a routine antiphospholipid assay for female candidates for IVF, and when it is confirmed, treatment is required by Anticoagulants.