Application Value of CEUS LI-RADS v.2017 in Focal Liver Lesions of Patients with a High Risk for Hepatocellular Carcinoma
Author:
Chen Huihui1, Yang Dan1, Wang Huihui2, Hu Jin Ming3
Affiliation:
1. Hangzhou Hospital for the Prevention and Treatment of Occupational Disease 2. The First Affiliated Hospital of Ningbo University 3. Zhejiang Youth Hospital
Abstract
Abstract
Purpose
This goal of this research is to investigate the practical value with regards to the data system (LI-RADS) v.2017 as well as contrast-enhanced ultrasound (CEUS) liver imaging reporting for focal liver lesions (FLLs) in patients at high-risk of hepatocellular carcinoma (HCC).
Method
The research included 127 high risk patients with HCC, comprising a total of 148 FLLs. All lesions were verified through pathology. Relying on CEUS LI-RADS v.2017, two independent radiologists categorized the lesions and evaluated inter-observer agreement by Cohen’s kappa. Finally, the classification of inconsistent lesions was discussed and agreed upon. The diagnostic accuracy of each classification was calculated based on the pathological results.
Results
The cohort included 108 males and 19 females, aged 37–82 (mean = 59.93 ± 10.09) years, with a lesion size range of 0.8–15 (mean = 3.95 ± 2.88) cm. Through the Kappa test, the interobserver agreement was high in the classification of FLLs (ĸ = 0.670, P = 0.000). Of the 148 FLLs, 4 and 3 lesions were categorized as an LR-1 and LR-2, correspondingly, all of which were pathologically benign. 6 lesions were categorised as an LR-3, comprising 3 benign and 3 malignant lesions. The diagnostic accuracy of benign versus malignant lesions was approximately 50%. 18 lesions were categorised as LR-4 including 13 malignant lesions (13/18, 72.22%); 102 lesions were categorized as LR-5, with 101 pathologically confirmed malignant lesions (101/102, 99.02%); 8 lesions were categorized as LR-TIV and all of them were malignant; finally, 7 lesions were classified LR-M and with 5 confirmed malignancies (5/7, 71.43%).
Conclusions
LR1/2 and LR4/5/TIV/M demonstrated a high degree of diagnostic accuracy for the delineation between benign and malignant lesions respectively. The classification criteria demonstrated reliable interobserver consistency for the classification of FLLs.
Publisher
Springer Science and Business Media LLC
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