NRBC Concentrations Over Time in Neonates with Moderate to Severe NE with and without Sentinel Events

Abstract

Abstract Objective: To study the serum concentrations of NRBC over time in neonates with moderate to severe NE. Study Design: A retrospective cohort study with subjects subdivided into three groups based on definite sentinel events (n=52), probable sentinel events (n=20) and no history of sentinel events (n=63). Peak absolute NRBC concentration and NRBC/100 WBC were compared between groups and compared with MRI Injury score, cord and admission pH/base deficit. Results: Absolute NRBC concentration peaked at 24.05 hours after birth (CI: 15.30- 32.79), 17.56 hours after birth (CI: 7.35-27.77), and 39.81 hours after birth (CI: 28.73-50.89) in each respective group. The peak in absolute NRBC correlated with the severity of injury in the grey matter in group 2 and white matter in groups 1 and 2. Higher peak absolute NRBC value correlated to a lower admission ABG pH (p<0.05). Conclusion: NRBC peak at 24 hours after birth in neonates with sentinel events.