Clinical value of combined preoperative-postoperative neutrophil-to-lymphocyte ratio in predicting the prognosis of hepatocellular carcinoma after radiofrequency ablation

Author:

Ni ZiHao1,Wu BoLin1,Liu Zhao1,Wang QiuCheng1,Han Xue1,Cheng Wen1,Guo CunLi1

Affiliation:

1. harbin medical university cancer hospital

Abstract

Abstract Objective: Previous studies have only focused on the prognostic significance of neutrophil-lymphocyte ratio (NLR) preoperatively or postoperatively; however, the significance of combined preoperative and postoperative NLR (PP-NLR) remains unknown. We investigated the value of preoperative and postoperative NLR and PP-NLR in predicting prognosis after radiofrequency ablation (RFA) in patients with hepatocellular carcinoma (HCC). Methods: Patients with hepatocellular carcinoma (HCC; n=108) who had undergone RFA between January 2018 and June 2019 at Harbin Medical University were retrospectively analyzed determination of optimal thresholds for leukocytes, lymphocytes, neutrophils and NLR before and after RFA. Risk factors for early HCC recurrence and risk factors affecting recurrence-free survival (RFS) were analyzed using univariate and multivariate Cox hazard ratio models. Plot Kaplan-Meier survival curves. Results: Respective preoperative and postoperative optimal thresholds were as follows: neutrophils, 3.431 and 4.975; leukocytes, 5.575 and 6.61; lymphocytes, 1.455 and 1.025; and NLR, 1.53 and 4.36. Univariate analysis revealed tumor number; alpha-fetoprotein level; postoperative leukocytes, lymphocytes, NLR, and neutrophils; preoperative neutrophils and NLR; and PP-NLR to be factors influencing early recurrence and RFS. Multivariate analysis showed that PP-NLR was an independent risk factor for poor RFS and early recurrence in HCC patients after RFA. Conclusion: Patients with high preoperative NLR, neutrophils, and alpha-fetoprotein level; high postoperative NLR, neutrophils, and leukocytes; low postoperative lymphocytes; and multiple tumors may have shorter RFS and a higher possibility of early recurrence. PP-NLR was more effective for predicting the prognosis than preoperative or postoperative NLR alone.

Publisher

Research Square Platform LLC

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