Water dynamics on the structural properties of amino acid in presence of NSAID: An approach through dielectric spectroscopy

Abstract

Abstract Present work reports the dielectric response for non-steroidal anti-inflammatory drugs (NSAID) 2-[2-[2-[(2,6-dichlorophenyl)amino]phenyl]acetyl] oxyacetic acid (Aceclofenac) in the aqueous leucine solution at different concentrations and temperatures (298.15 K-283.15 K) using time domain reflectometry technique in the frequency region 1 GHz to 30 GHz. Dielectric parameters such as complex permittivity (ε*), dielectric constant (ε), dielectric relaxation time (τ), dipole moment (µ) and Kirkwood correlation factor (g) have been calculated and the study is corroborated by the thermodynamic parameters such as molar enthalpy of activation (∆H), entropy of activation (∆S) and free energy of activation (∆F) to give insight into the structural dynamics.