Abstract
Objectives The aim of this study was to compare the effects of RYR (Red Yeast Rice), liraglutide and atorvastatin on metabolic parameters in rats fed a HFD (High-Fat Diet).Methods At the end of the study, FPG (Fasting Plasma Glucose), C-LDL (LDL Cholesterol), TC (Total Cholesterol), TG (Triglyceride) levels, AIP (Atherogenic Index of Plasma) and TyG (Triglyceride Glucose Index) indices of the rats were compared.Results The C-LDL level of the group fed with HFD and given RYR in the last 4 weeks decreased significantly compared to the CG group fed only with HFD for 10 weeks (p < 0.001). Liraglutide significantly reduced TGs, TyG index and AIP index compared to HFD-fed CG alone (p < 0.001).Conclusion As a result of sufficient studies on RYR, RYR supplementation may be considered in addition to oral drug therapy for patients with hyperlipidemia. When used in accordance with its indication. Liraglutide can be reduce the AIP value as well as the single-parameter lipid values measured for the risk of hyperlipidemia and atherosclerosis, which are the causes of cardiovascular diseases.