The association of ICSI outcomes with semen and blood Bisfenol A concentrations of the male partner

Abstract

Abstract This study investigates the association of blood and semen Bisfenol A (BPA) levels of the male partner on the reproductive outcome in intracytoplasmic sperm injection treatment cycles (ICSI). For this prospective study (clinicaltrials.gov identifier: NCT02703584) blood and semen samples of the male partner of the seventy five women who had ICSI were analyzed. The study group consisted of men who had ICSI for male factor infertility other than azoospermia, while men with normal spermiogram whose partnets underwent ICSI due to tubal factor infertility were taken as the study group. Habitual consumption of drinking water from plastic carboys/bottles (PBW) at home was also questioned in both groups as it was considered as chronic BPA exposure. The association of ICSI outcome with blood BPA (bBPA) and semen BPA (sBPA) levels were analyzed in both groups. In the patients who failed to get pregnant, bBPA levels of the male partner was statistically significantly higher then the ones who achieved pregnancy in both groups. Embryo development arrest was found significantly higher in the patients who have high sBPA levels. No significant correlation was found between sperm parameters and bBPA levels in both groups. A negative correlation was found between sBPA levels and total sperm count and progressive sperm motility in men who consumed PBW. Although, PBW BPA levels were not different, bBPA levels were found to be significantly lower in those who consumed tap water than those who used PBW. Elevated serum BPA level was associated with a significantly lower clinical pregnancy rate.