NMR studies of complex formation between natural cyclodextrins and benzene-Reference-Cited by-同舟云学术

NMR studies of complex formation between natural cyclodextrins and benzene

Published:2023-12-21 Issue: Volume: Page:
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Author:

Szczupaj Gabriela Kaja¹,Wójcik Jacek¹,Ejchart Andrzej²,Nowakowski Michał Eligiusz¹

Affiliation:

1. Faculty of Chemistry, Biological and Chemical Research Centre, University of Warsaw

2. Institute of Biochemistry and Biophysics, Polish Academy of Sciences

Abstract

Abstract Inclusion complexes of benzene (Bz) with cyclodextrins (CD) have been investigated so far using non-NMR techniques resulting in conflicting data. Here, the first application of NMR spectroscopy in combination with rigorous statistical analysis of the results has allowed us to determine accurately the stoichiometry of complexes and their association constants. Titration measurements have been performed by 1H NMR spectroscopy in D2O at a magnetic field B0 of 14.1 T. αCD and γCD host molecules form weak 1 : 1 complexes with Bz. In contrast, Bz and βCD build 1 : 1 and 2 : 1 complexes coexisting in solution with large binding constants. Binding of second benzene molecule is strongly cooperative.

Publisher

Research Square Platform LLC

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