Affiliation:
1. Xiamen University
2. Henan University of Science and Technology
3. Department of dermatology, The Third People's Hospital, Affiliated Hangzhou Dermatology Hospital Zhejiang University School of Medicine
Abstract
Abstract
Objective: A large number of studies had been published over the past decade on the association between the severity of atopic dermatitis and biomarkers. Our purpose is to screen relevant studies and comprehensively evaluate correlations between biomarkers and disease severity, which is an update for the researches in past decade.
Methods: Three databases (PubMed, EMBASE and Cochrane) were searched systematically, and relevant studies were selected according to the inclusion and exclusion criteria.
Results: A total of 49 articles reporting 98 different biomarkers in 4148 patients were rigorously evaluated. Ten markers (serum levels of CCL17, IgE, CCL27, CCL22, IL-13, IL-18, lactate dehydrogenase (LDH), IL-17A, vitamin D, and eosinophils) were used in at least four studies and meta-analyzed.
Conclusions: CCL27, IL-18 and IL-17A were found to be the most reliable biomarkers in the study, with correlation coefficients of 0.62, 0.62 and 0.61, respectively. Other biomarkers that may be useful but require more research include CCL17, IL-13, IgE, LDH, Eosinophil and Vitamin D.
Publisher
Research Square Platform LLC