Evaluating different methods for kidney recellularization-Reference-Cited by-同舟云学术

Evaluating different methods for kidney recellularization

Published:2024-03-13 Issue: Volume: Page:
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Author:

Luque-Badillo Ana C.¹,Monjaras-Avila Cesar U.¹,Adomat Hans¹,So Alan¹,Chavez-Munoz Claudia¹

Affiliation:

1. University of British Columbia

Abstract

Abstract This study explores a potential solution to the shortage of kidneys for transplantation in end-stage renal disease (ESRD). Currently, kidney transplantation is the best option, but there aren't enough organs available. The researchers used tissue engineering to evaluate the possibility for creating kidneys for transplantation. They used pig kidneys, removing cells through a process called decellularization while preserving the organ's microarchitecture. The researchers then perfused pig kidney cells and human red blood cells to the empty kidney structure to recreate it. The methodologies used, showed promising results, suggesting a hopeful method to address the organ shortage. This proof-of-concept lays the foundation for potentially applying this technology to human kidneys, which could significantly improve outcomes for ESRD patients by providing more transplantable organs.

Publisher

Research Square Platform LLC

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