Association of Gene Polymorphisms in Programmed Death Ligand-1 (PD-L1) with susceptibility and prognosis of B-Cell Non-Hodgkin Lymphoma in a Cohort of Egyptians

Abstract

Abstract Purpose: To investigate the possible relation between polymorphisms of PD-L1 rs4143815 and rs2890658 with the susceptibility and prognosis of B-NHL in a Cohort of Egyptians, we conducted a case-control study. Methods: Genotyping was done using real-time polymerase chain reaction (real-time PCR) for 100 adult B-NHL patients and 100 healthy adults (controls). Results:Our results did not show any significant association between PD-L1 (rs4143815, rs2890658) SNPs and risk of B-NHL occurrence. However, the relationship between allele distribution of rs4143815 (C>G) and rs2890658 (A>C) and adverse clinico-pathological features of B-NHL patients revealed positive results. Conclusions: Our results provided the first evidence that PD-L1 rs4143815 (C>G) and rs2890658 (A>C) are not molecular susceptibility markers for B-NHL in Egyptians, at least in the studied population. However, these polymorphic sites could be candidates for predicting some adverse clinico-pathological features and might have a potential prognostic role in B-NHL.