Dorsal Striatum in Obsessive-Compulsive Disorder: A Texture Analysis Study

Abstract

Abstract Aim: The aim of this study is to examine the MR images of the dorsal striatum, which is known to play a role in the etiopathogenesis in patients with obsessive-compulsive disorder (OCD), using texture analysis method. Methods: Twenty-eight OCD patients with brain MRI images in the Hospital Picture Archiving and Communication System were included in the study. The control group were formed with 28 healthy individuals of the same age and gender as the study group. T1 weighted MRI images were obtained with 1.5T systems. All regions of the putamen, and caudate nucleus were selected individually in the axial images that best represent the anatomy, without exceeding their borders. Both symmetrical locations were used as separate samples (56 samples caudate 56 samples putamen for both groups). Results: Most of the parameters for both locations showed statistically significant differences. ROC curve analysis showed high sensitivity and specificity for mean values for both nuclei. Logistic regressions for values to determine the effects of the calculated parameters of the nuclei on the probability of participants having OCD yielded important findings. Conclusion: Tissue parameters in the dorsal striatum of OCD patients were found to be different from healthy controls. The study findings demonstrated that tissue analyzes are a useful technique for demonstrating tissue changes in the dorsal striatum using MR images of patients with OCD.