Exploration of the shared pathways and common biomarker LY96 in Endometriosis and Systemic lupus erythematosus using integrated bioinformatics analysis

Author:

Huang Jin1,Ruan Xuelian1,Chen Yongling1,Zhong Ziqing1,Nie Jiaqi1,Zeng Moqiyi1,Tao Xiang1,Qin Xue1,Chen Hua Ping1

Affiliation:

1. First Affiliated Hospital of Guangxi Medical University

Abstract

Abstract

Endometriosis (EMS) is a chronic gynecological disorder that affects 5–10% of women of reproductive age, and Systemic lupus erythematosus (SLE) is one of the most prevalent systemic autoimmune diseases. Despite clinical evidence suggesting potential associations between EMS and SLE, the underlying pathogenesis is yet unclear. This article aimed to explore the shared gene signatures and potential molecular mechanisms in EMS and SLE. Microarray data were downloaded from the Gene Expression Omnibus (GEO) database and used to screen for differentially expressed genes (DEGs) in the SLE datasets. A weighted gene co-expression network analysis (WGCNA) was used to identify the co-expression modules of EMS. cytoscape software and three machine learning algorithms were used to determine critical biomarkers, and a diagnostic model was built using the XG-Boost machine learning algorithms. Immune cell infiltration analysis was used to investigate the correlation between immune cell infiltration and common biomarkers of EMS and SLE. Results revealed that shared genes enriched in immune-related pathways and inflammatory responses. The area under the receiver operating characteristic (AUROC) curve and the Precision-Recall (PR) curves showed satisfactory performance of the model. immune cell infiltration analysis showed that the expression of hub genes was closely associated with immune cells. RT-qPCR results indicated that LY96 might be the best biomarker for EMS and SLE.

Publisher

Research Square Platform LLC

Reference44 articles.

1. The link between immunity, autoimmunity and endometriosis: a literature update;Zhang T;Autoimmun Rev,2018

2. The Immunopathophysiology of Endometriosis;Symons LK;Trends Mol Med,2018

3. Systemic lupus erythematosus;Kaul A;Nat Rev Dis Primer,2016

4. Is endometriosis an autoimmune disease?;Gleicher N;Obstet Gynecol,1987

5. The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis;Shigesi N;Hum Reprod Update,2019

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3