LncRNA SNHG1 promotes colorectal cancer cells invasion and migration by upregulating SERPINA3

Abstract

Abstract Colorectal cancer metastasis (CRC) is the main reason for patients’ death and remains a crucial clinical challenge. LncRNAs play kinds of important roles in the progression of CRC metastasis, but the implied mechanisms are still unclear. In our research, we studied the lncRNA small nucleolus host gene 1 (SNHG1) which was up-regulated in CRC tissues, and the high expression of lncRNA SNHG1 was correlated with poor prognosis of patients. Functionally, lncRNA SNHG1 acted as an oncogene and promoted CRC cells invasion and migration. Mechanistically, lncRNA SNHG1 mainly located in cell cytoplasm, in which it recruited heterogeneous nuclear ribonucleoprotein D (HNRNPD) and increased the mRNA stability of serpin family A member 3 (SERPINA3), and then subsequently upregulated SERPINA3 expression to facilitated CRC cells invasion and migration. Our finding demonstrated a different role of lncRNA SNHG1 in the cytoplasm and lncRNA SNHG1/HNRNPD-SERPINA3 might serve as a potential therapy for CRC.