lncRNA: a promising target for cataracts-Reference-Cited by-同舟云学术

lncRNA: a promising target for cataracts

Published:2023-05-03 Issue: Volume: Page:
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Author:

dong xiaoming¹,liu yuxuan²,ji liyang³,wang jing⁴,zhang jisong³

Affiliation:

1. Cataract and Intraocular Lens Institute, Shenyang Aier Excellent Eye Hospital, Shenyang 110000, Liaoning Province, China,

2. Shenyang Aier Excellent Eye Hospital, Shenyang 110000, Liaoning Province, China,

3. Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, Eye Hospital of China Medical University, Key Laboratory of Lens Research of Liaoning Province, Shenyang, China

4. Aier School of Ophthalmology, Central South University, Changsha 410000, Hunan Province, China,

Abstract

Abstract Long noncoding RNAs (lncRNAs) are nonprotein-coding transcripts containing >200 nucleotides. lncRNA was first considered the “noise” of genome transcription and had no biological function. With the deepening of research, lncRNA has been found to regulate gene expression at epigenetic, transcriptional, and translation levels, thus affecting cell proliferation, apoptosis, viability, immune response, and oxidative stress. More and more studies have shown that the expression and function of lncRNA are closely related to ophthalmic diseases, such as cataracts, glaucoma, and diabetic retinopathy. This review summarized the classification and mechanism of known lncRNAs and the role of lncRNAs in eye diseases, especially in cataracts, and further clarified their mechanism.

Publisher

Research Square Platform LLC

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