Behçet's disease in pregnancy:A case report and literature review

Abstract

Abstract Background：Behçet's disease (BD) in pregnancy is a relatively rare disease,and there are no guidelines for it. It is such a rare disease that obstetricians have not enough experience in diagnosis and treatment. Herein,we introduce the process of diagnosis and treatment of a patient with BD in pregnancy. Case presentation：A 20 years old woman, gravida 2, para 1,presented in our inpatient department with recurrent oral and genital ulcers at 28 weeks and 3 days of gestation. Considering the specility of the patient,we started the first multidisciplinary consulation to make sure treatment regimens. However,the initial treatment was not effective, and the patient had a fever for four days. So we initiated the second multidisciplinary consulation. The final treatment regimen included azithromycin, hydroxychloroquine,prednisone,low-molecular heparin calcium. The clinical symptoms were gone and the female neonate was delivered successfully. No relapse was found during 4-month follow-up. Conclusions：The critical issues in the treatment are medication safety in pregnant women and avoidance of adverse pregnancy outcomes. Multidisciplinary consulation is a effective way to solve the treatment regimens. Obstetricians should closely monitor disease progression and pay attention to complications in time to minimize adverse pregnancy outcomes.