Association between muscle-fat ratio and sarcopenia in older adults with hypothyroidism

Abstract

Abstract Objectives To test the body composition To investigate the associationbetween body fat (BF%)，muscle-fat ratio and sarcopenia in older adults with hypothyroid。 Methods A total of 543 older adults with hypothyroidism were included in this cross-sectional study. Appendicular skeletal muscle (ASM), handhandgrip strength and gait speed were measured to diagnose sarcopenia according to the updated Asian Working Group for Sarcopenia (AWGS) 2019 criteria. Body composition data were tested using a bioresistive antibody composition analyzer (model: Tsinghua Tongfang BCA-2A).Levels of serum Lipids and thyroid hormone were also determined. Results The prevalence of sarcopeniain all participants was 25.51%, of which 18.58% were male and 31.54% females. The Pearson’s correlation analysis revealed that BF% was positively correlated with ASMI in both male and female patients (R=0.530, P=0.001; R=0.649, P=0.001), and positively correlated with handhandgrip strength in males and gait speed in females (R=0.230, P=0.014; R=0.242, P=0.005). Muscle-fat ratio was negatively correlated with ASMI in both sexes (R=-0.496, P=0.001; R=-0.291, P=0.001) and with handhandgrip strength in male patients (R=-0.327, P=0.001).After adjusting for all potential confounders, sarcopenia was positive associated with BF% (male, OR: 0.805, 95% CI: 0.726-0.894, P< 0.001; female, OR: 0.876, 95% CI: 0.811-0.946, P=0.004), and positive associated with body mass index (BMI) (male, OR: 0.678, 95% CI: 0.570-0.807, P<0.001; female, OR: 0.618, 95% CI: 0.484-0.790, P<0.001).But decreased muscle-fat ratio was a risk factor for sarcopenia(male, OR: 1.975, 95% CI: 1.412-2.763, P<0.001; female, OR: 2.330, 95% CI: 1.280-4.242, P=0.006).No significant differences were found in Lipids, thyroid hormone between older adults with hypothyroidism with and without sarcopenia. Conclusion older adults with hypothyroidism have a higher risk of sarcopenia,lower BF% and BMI were linked to an increased risk of sarcopenia in older adults with hypothyroidism.suggesting the importance of assessing muscle fat ratio and BF% rather than BMI alone to manage sarcopenia.older adults with hypothyroidism should maintain BMI and BF%, timely detection of body composition and control of muscle fat ratio are important measures for the prevention and treatment of sarcopenia.