An Effective, Mechanochemical One-Pot Multi Gram Scale Synthesis of N-Bridged Fused Heterocycles under Solvent- Free Conditions

Abstract

Abstract KI/TBHP mediated C–N and C–S bonds formation of ketones with 2-aminopyridines under grinding condition to give the imidazo[1,2-a]pyridines and imidazo[2,1-b]thiazole under ecologically friendly conditions have been established. The reaction proceeds under solvent-free condition, without using any metal catalyst and displays high yields. This protocol has several notable features including mild reaction condition, base-free, broad functional group tolerance and good reaction yield, avoid the use of expensive and air-sensitive reagents and can be performed under ambient reaction conditions.