Affiliation:
1. Columbia University
2. Brigham and Women's Hospital, Harvard Medical School
3. Fred Hutchinson Cancer Center
4. Fred Hutchinson Cancer Research Center
5. Brigham and Women's Hospital
6. Mailman School of Public Health
7. David Geffen School of Medicine at University of California
8. Instituto Nacional de Cancerologia
9. Pennsylvania State University College of Medicine
10. University of North Carolina
Abstract
Abstract
Ambient air pollution has been associated with bone damage. However, no studies have evaluated the metabolomic response to air pollutants and its potential influence on bone health in postmenopausal women. We analyzed data from WHI participants with plasma samples. Whole-body, total hip, femoral neck, and spine BMD at enrollment and follow-up (Y1, Y3, Y6). Daily particulate matter NO, NO2, PM10 and SO2 were averaged over 1-, 3-, and 5-year periods before metabolomic assessments. Statistical analyses included multivariable-adjusted linear mixed models, pathways analyses, and mediation modeling. NO, NO2, and SO2, but not PM10, were associated with taurine, inosine, and C38:4 phosphatidylethanolamine (PE), at all averaging periods. We found a partial mediation of C38:4 PE in the association between 1-year average NO and lumbar spine BMD (p-value: 0.032). This is the first study suggesting that a PE may partially mediate air pollution-related bone damage in postmenopausal women.
Publisher
Research Square Platform LLC