Association between CTLA-4 +49A/G (rs231775) polymorphism and the risk of autoimmune thyroid diseases: A systematic review and meta-analysis

Abstract

Abstract Background Previous studies have investigated the association between CTLA-4 + rs23177549A/G gene polymorphism and the risk of autoimmune thyroid disease (AITD), but there are some conflicting findings among those studies. This study aimed to summarize relevant evidence available regarding the association of CTLA-4 + rs23177549A/G gene polymorphism and AITD. Materials and Methods An extensive literature search was conducted in PubMed, EMBASE, and Web of Science for pertinent papers published up until January 24th, 2022. We included all the case-control studies that investigatedthe association between the rs23177549A/G gene polymorphism and susceptibility to AITD. Results 46 case-control studies met the inclusion criteria and were included in this analysis in total. Our results indicated that CTLA-4 + rs23177549A/G polymorphism was not associated with increased susceptibility to AITD. No significant association with CTLA-4 + rs231775 49A/G polymorphism was detected for the risk of Graves' disease and HT. Subgroup analysis by race showed significant association in Asians, except in the recessive genetic model. Conclusion There was no significant association between the CTLA-4 + rs2317749A/G polymorphism and the risk of autoimmune thyroid diseases.