A retrospective study of pyogenic liver abscess concentrating on the relationship between strain and the location of the intrahepatic abscess

Abstract

Abstract Aims: PLA (pyogenic liver abscess) has become a common disease, but the percentage of positive cultures of PLA is low. This study summarizes methods for empirically guiding the administration of PLA even without culture results. Method: The clinical data, clinical characteristics, drug resistance, and liver abscess culture results of 398 patients with PLA were recorded and analyzed retrospectively. Results: For the new findings, there was a significant correlation between KP (Klebsiella pneumoniae) and a high incidence of right lobe of PLA,(P<0.001); There was significant correlation between E.coli(Escherichia coli) and a high incidence of left lobe of PLA.༈P<0.001༉ Conclusions: In patients with PLA whose abscess lesion was located in the right liver, KP was the first consideration, and a third-generation cephalosporin or third-generation cephalosporin/enzyme inhibitor was started. When the abscess is located in the left liver, the presence of E. coli should be considered, and treatment with third-generation cephalosporin/enzyme inhibitors or carbapenems should be started. When the abscess is located in the caudate liver, the pathogenic bacteria may be Streptococcus. Metronidazole and ampicillin are not recommended as first-line anti-infective agents for PLA.