Polymorphisms rs2073618 and rs3102735 in TNFRSF11B with the Susceptibility to Gastric Cancer

Author:

Tang Xuan1,Dai Zhe1,Gong Dandan1,Pan Huiwen1,Man Changfeng1,Zhang Shiqi2,Gao Zhenjun3,Wang Xiaoyan2,Fan Yu1

Affiliation:

1. Affiliated People's Hospital of Jiangsu University

2. Affiliated Suqian First People's Hospital of Nanjing Medical University

3. Fudan University

Abstract

Abstract

Purpose This study aims to explore the potential association between TNFRSF11B gene polymorphisms (rs2073618 and rs3102735) and the risk of gastric cancer in the Chinese Han population. Methods A case-control study was conducted involving 577 individuals diagnosed with primary gastric cancer and 678 healthy volunteers. Genomic DNA was extracted from whole blood samples, and the target gene fragment was amplified via PCR. Genotyping and allele analysis were subsequently performed using the snapshot technique. Results In this retrospective research, it was discovered that the TNFRSF11B rs3102735 T > C polymorphism is significantly correlated with a heightened risk of gastric cancer. Conversely, the variant allele of the rs2073618 polymorphism demonstrated no significant association with susceptibility to gastric cancer. During the subgroup analysis of the rs3102735 polymorphism, a notably heightened risk of gastric cancer was observed in the group aged above 62 years. Stratified analyses indicated that the TNFRSF11B rs2073618 polymorphism didn’t exhibit an association with gastric cancer susceptibility across varying ages, genders, smoking and alcohol drinking. Conclusion Our research indicated a link between smoking and the incidence of gastric cancer. Additionally, we identified a link between gastric cancer and the TNFRSF11B rs3102735 polymorphism, but not with the rs2073618 polymorphism. TNFRSF11B rs3102735 CC mutated homozygote genotype may be an indicator of gastric cancer.

Publisher

Springer Science and Business Media LLC

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