Phytochemical analysis of the extract from berries of Schisandra chinensis Turcz. (Baill.) and its anti-platelet potential in vitro

Author:

Sławińska Natalia1,Kontek Bogdan1,Żuchowski Jerzy2,Moniuszko-Szajwaj Barbara2,Białecki Jacek1,Zakrzewski Kamil1,Bogusz Paulina3,Stochmal Anna2,Olas Beata1

Affiliation:

1. University of Lodz

2. Institute of Soil Science and Plant Cultivation – State Research Institute

3. Lukasiewicz Research Network – New Chemical Synthesis Institute

Abstract

Abstract

Schisandra chinensis Turcz. (Baill.) is a dioecious vine, belonging to the Schisandraceae family. Itsberries show several beneficial activities, including cardioprotective, antioxidant, and anti-inflammatory. We examined the chemical content of the extract from S. chinensis berries, as well as its antiplatelet potential in washed human blood platelets and whole blood in vitro. We assessed effect of the extract on several hemostasis parameters, including thrombus formation in full blood, platelet activation and adhesion, and coagulation times. Moreover, we evaluated the cytotoxicity of the extract against blood platelets based on extracellular lactate dehydrogenase (LDH) activity. The most important constituents of the extract were dibenzocyclooctadiene lignans; schisandrin was the dominant compound. The extract inhibited thrombus formation, agonist-stimulated platelet activation and adhesion, and was not cytotoxic. These results suggest that S. chinensisberries can be used as a safe, natural supplement with anti-platelet properties. However, more studies are needed to determine their mechanisms of action and in vivo efficiency.

Publisher

Springer Science and Business Media LLC

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