Fractional Amplitude of low frequency fluctuation changes in children with anisometropic amblyopia: a resting-state fMRI study-Reference-Cited by-同舟云学术

Fractional Amplitude of low frequency fluctuation changes in children with anisometropic amblyopia: a resting-state fMRI study

Published:2023-06-01 Issue: Volume: Page:
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Author:

Yu Xueliang¹,Zhao Feng¹,Lu Weizhao²,Chen Di³,Li Xiujuan⁴,Wang Yi³,Wang Baojian⁴

Affiliation:

1. Dezhou Municiple Hospital

2. Shandong First Medical University & Shandong Academy of Medical Sciences

3. The Second Affiliated Hospital of Shandong First Medical University & Shandong Academy of Medical Sciences

4. The Affiliated Taian City Central Hospital of Qingdao University

Abstract

Abstract Aims: This study evaluates the changes of brain spontaneous activity in patients with anisometropia amblyopia compared with healthy controls. Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data of 18 children patients with anisometropia amblyopia（PAA group）and 14 healthy children (control group) were collected. Fractional amplitude of low frequency fluctuation (fALFF) was used to assess brain spontaneous activity changes between the two groups. Two-sample t test was used for statistical analysis of fALFF value between groups. Pearson correlation was used to analyze the correlation between fALFF value in anisometropic amblyopia and clinical information. Results: Compared with healthy controls, children with anisometropia amblyopia showed higher fALFF values in the middle right occipital gyrus and left central paracentric lobule. While fALFF value in the left middle frontal gyrus in children with anisometropic amblyopia was lower than that of healthy controls. There were no significant correlations between clinical information and mean fALFF values in PAA group. Conclusion: Rs-fMRI fALFF analysis of children with anisometropic amblyopia reflects brain spontaneous activity changes in the visual cortex.

Publisher

Research Square Platform LLC

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