Causal Relationship between Genetically Predicted Psychiatric Disorders and Colorectal Cancer Risk: A Two-Sample Mendelian Randomization
Author:
Liu Yi-Fan1, Jia Hui2, Wu Miao-Qing1, Cao Di1, Lv Guang-Zhao1, Li Cong1, Zhang Rong-Xin1, Chen Gong1
Affiliation:
1. Sun Yat-sen University Cancer Center 2. The Eighth Affiliated Hospital of Sun Yat-sen University
Abstract
Abstract
Purpose The main purpose of this study was to examine the causal relationship between various psychiatric disorders and colorectal cancer risk using a two-sample Mendelian randomization analysis. The research question aimed to determine whether a specific psychiatric disorder has a causal link with colorectal cancer.Methods We utilized publicly accessible genome-wide association studies (GWAS) data on psychiatric disorders, including Attention Deficit Hyperactivity Disorder (ADHD), Major Depressive Disorder (MDD), Insomnia, Schizophrenia (SCZ), Bipolar Disorder (BIP), Worry, Panic, Autism Disorder, and Neuroticism. Causal analyses were executed using inverse variance weighting (IVW) and supplemented with methods for sensitivity assessment, pleiotropy testing, and outlier exclusion.Results Our analysis identified a causal relationship solely between BIP and colorectal cancer (OR = 0.90, 95% CI: 0.81–0.99, P = 0.03). Additional analysis revealed a causal effect of type I BIP on colorectal cancer (OR = 0.90, 95% CI: 0.93–0.98, P = 0.01). We found no evidence of a causal impact for other mental disorders on colorectal cancer risk.Conclusion Our study implies that type I BIP exerts a negative causal influence on colorectal cancer risk, offering new perspectives for the study of prevention strategies and pathological mechanisms of colorectal cancer.
Publisher
Research Square Platform LLC
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