Affiliation:
1. Oregon Health and Science University Hospital
Abstract
Abstract
BACKGROUND
Sinus node dysfunction (SND) with junctional rhythm (JR) is common after the Fontan operation. Atrial pacing (AP) restores atrioventricular (AV) synchrony, but the placement of a pacemaker carries significant morbidity.
OBJECTIVES
To study the impact of AP on echocardiographic parameters of function in Fontan patients with SND and JR.
METHODS
Nine Fontan patients with AP for SND and JR were prospectively studied with echocardiography in the following conditions – baseline paced rhythm, underlying JR and, if possible, slow-paced rhythm below their baseline paced rate (~ 10 bpm faster than their JR rate).
RESULTS
Cardiac index was significantly lower in JR (3 ± 1.1 L/min/m2) vs AP (4.2 ± 1.4 L/min/m2; p = 0.002). Diastolic function also significantly worsened with increased ratio of early diastolic mitral inflow velocity to early diastolic mitral annulus velocity (E/e’ ratio) by tissue Doppler imaging (TDI) in JR (11.6 ± 4.6) vs AP (8.8 ± 2.2, p = 0.016). Pulmonary venous flow reversal was present in 0/9 patients in AP and 7/9 in JR (p = 0.016). There were no significant differences in these echocardiographic measurements between the paced and slow-paced conditions.
CONCLUSIONS
When compared to AP, JR was associated with a significant reduction in cardiac output and diastolic function, and an increased prevalence of pulmonary vein flow reversal. There were no differences between paced and slow-paced conditions, suggesting that AV synchrony rather than heart rate was primarily contributing to cardiac output. Further studies are needed to understand the chronic impact of JR on Fontan outcomes.
Publisher
Research Square Platform LLC
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