Malnutrition- Inflammation- Atherosclerosis (MIA) syndrome associates with periodontitis in end-stage renal disease patients undergoing hemodialysis: A cross-sectional study

Abstract

Abstract Aim Malnutrition-inflammation-atherosclerosis (MIA) syndrome is a significant risk factor for mortality in patients undergoing hemodialysis. This study aimed to investigate the association between MIA syndrome and oral health status in hemodialysis patients.Material and methods A cross-sectional study was conducted on 254 hemodialysis patients. Comprehensive medical and dental examinations were performed. Three components were included to define MIA syndrome: albumin levels, serum high-sensitivity C-reactive protein, and history of cardiovascular events as indicators of malnutrition, inflammation, and atherosclerosis, respectively. The association of MIA syndrome components with periodontitis and occlusal support was examined by multiple-ordered logistic regression analysis.Results Of 254 participants, 170 (66.9%) had at least one component of MIA syndrome. After adjusting for possible confounding factors, severe periodontitis was significantly associated with presence of more components of MIA syndrome (odds ratio [OR]: 2.40, 95% confidence interval [CI], 1.33–4.34, p = 0.004) and inflammation and malnutrition components (OR: 2.21 and 3.31, 95% CI: 1.10–4.43 and 1.64–6.65, p = 0.030 and 0.001). On the other hand, occlusal support was not significantly associated with MIA syndrome or any of its components.Conclusion Periodontitis is associated with MIA syndrome, particularly with inflammation and malnutrition in hemodialysis patients, independent of occlusal support.