Adaptability analysis of the ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone in China-Reference-Cited by-同舟云学术

Adaptability analysis of the ceftriaxone-resistant Neisseria gonorrhoeae FC428 clone in China

Published:2023-06-15 Issue: Volume: Page:
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Author:

Li Yamei¹,Yang Yang²,Cao Wenling³,Xiu Leshan⁴,Wang Di¹,Gu Weiming²,Peng Junping¹

Affiliation:

1. Chinese Academy of Medical Sciences & Peking Union Medical College

2. Tongji University School of Medicine

3. Guangzhou Institute of Dermatology

4. Shanghai Jiao Tong University School of Medicine

Abstract

Abstract We describe nine internationally spreading ceftriaxone-resistant FC428 clone-related Neisseria gonorrhoeae strains with a typical ceftriaxone-resistant phenotype (MIC ≥ 0.5 mg/L) isolated from Guangzhou and Shanghai between 2019 and 2020. The adaptability analysis further involved all FC428-related N. gonorrhoeae strains reported in China and our data demonstrated that three representative clones (MLST-ST1903_NG-STAR-ST1143, MLST-ST1600_NG-STAR-ST2208, and MLST-ST13943_NG-STAR-ST233) were observed to settle in China in evolution. Specifically, enhancing antimicrobial resistance surveillance of the three representative clones is crucial for understanding the transmission trajectory and optimizing therapy strategies.

Publisher

Research Square Platform LLC

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