mRNA vaccine encoding Gn Provides Protection Against Severe Fever with Thrombocytopenia Syndrome Virus in mice-Reference-Cited by-同舟云学术

mRNA vaccine encoding Gn Provides Protection Against Severe Fever with Thrombocytopenia Syndrome Virus in mice

Published:2023-06-29 Issue: Volume: Page:
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Author:

Nam Jae-Hwan¹^ORCID,Kim Jae-Yong²,Lee Soo-Yeon²,Choi Eun-Jin²,Jeon Kyeongseok³,Park Sang-In⁴,Park Hyeong-Jun⁴,Kwak Hye Won⁵,Kim Do-Hyung⁵,Bang Yoo-Jin⁴,Cho Nam-Hyuk³

Affiliation:

1. Catholic University of Korea

2. The Catholic University of Korea

3. Seoul National University College of Medicine

4. SMLbiopharm

5. SML Biopharm

Abstract

Abstract We developed a promising mRNA vaccine against Severe Fever with Thrombocytopenia Syndrome (SFTS), an infectious disease caused by the SFTS virus that is primarily transmitted through tick bites. Administration of lipid nanoparticle-encapsulated mRNA-Gn successfully induced neutralizing antibodies and T-cell responses in mice. The vaccinated mice were completely protected against a lethal SFTS virus challenge, suggesting that this mRNA vaccine may be an effective candidate for a successful SFTS vaccine.

Publisher

Research Square Platform LLC

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