Clinical, pathologic and molecular findings in 2 Rottweiler littermates with appendicular osteosarcoma

Author:

Silver Kate I.1,Mannheimer Joshua D.1,Saba Corey2,Hendricks William P. D.3,Wang Guannan3,Day Kenneth3,Warrier Manisha3,Beck Jessica A.1,Mazcko Christina1,LeBlanc Amy K.1

Affiliation:

1. National Cancer Institute, NIH

2. University of Georgia

3. Vidium Animal Health, A Subsidiary of The Translational Genomics Research Institute (TGen)

Abstract

Abstract Appendicular osteosarcoma was diagnosed and treated in a pair of littermate Rottweiler dogs, resulting in distinctly different clinical outcomes despite similar therapy within the context of a prospective, randomized clinical trial (NCI-COTC021/022). Histopathology, immunohistochemistry, mRNA sequencing, and targeted DNA hotspot sequencing techniques were applied to both dogs’ tumors to define factors that could underpin their differential response to treatment. We describe the comparison of their clinical, histologic and molecular features, as well as those from a companion cohort of Rottweiler dogs, providing new insight into potential prognostic biomarkers for canine osteosarcoma.

Publisher

Research Square Platform LLC

Reference80 articles.

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