Transcriptional landscapes and signaling pathways of LDHA inhibitor treated pancreatic ductal adenocarcinoma

Abstract

Abstract Lactate dehydrogenase (LDHA) is a metabolism-related enzyme that is involved in the progression of several cancers such as pancreatic ductal adenocarcinoma (PDAC). However, the mechanism of LDHA regulates the PDAC is largely unknown. In this study, we analyzed the RNA-seq data of LDHA inhibitor-treated PDAC cells and identified the transcriptional landscapes of these cells. We used the gene enrichment assays including KEGG and GO to further analyzed the potential signaling pathways. In addition, we constructed the PPI network and Reactome map to further identified the biological processes. We found the TNF signaling pathway and Cellular senescence are the major signaling pathways that involve the LDHA inhibitor-treated PDAC cells. We identified the top ten interactive genes including FN1, CCND1, HDAC1, NFKBIA, PPARG, HSPA5, AURKB, CXCR4, RUNX2, and IRF1. Our study may provide novel mechanisms for the treatment of PDAC.