Prevalence and Predictors of Anxiety and Depression in Chinese Women with Polycystic Ovary Syndrome undergoing Infertility Treatment

Abstract

Abstract Aim: To investigate the prevalence and predictors for anxiety and depression in Chinese women with polycystic ovary syndrome (PCOS) undergoing infertility treatment. Materials and Methods: This study was a secondary analysis of a randomized controlled clinical trial in which a total of 1,000 women with PCOS undergoing infertility treatment recruited from 27 hospitals across mainland China were enrolled. Anthropometric, endocrine, and metabolic parameters were measured at the baseline visit. Anxiety and depression state were evaluated according to the Self-Rating Anxiety Scale (SAS) and the Self-Rating Depression Scale (SDS). Mann–Whitney test and logistic regression were used to identify predictors for anxiety and depression. Results: A total of 19.86% of the women had anxiety, and the prevalence of mild, moderate, and severe anxiety were 16.45%, 2.91% and 0.50%, respectively. A total of 24.58% of the women had depression, and the prevalence of mild, moderate, and severe depression were 18.96%, 5.52% and 0.10%, respectively. The multivariate logistic regression results showed that age, acne score, and number of induced abortions were independent predictors for anxiety. In terms of depression, its related factors included age, hypertension, and duration of infertility. Conclusions: It seems that anxiety and depression among women with PCOS in our country were not as high as in Western countries. The dominating predictors for anxiety in PCOS were age, acne score, and number of induced abortions, and the major predictors for depression were age, hypertension, and duration of infertility. These predictors explored in this study may promote the development of individualized interventions for psychological disorders in such patients.